may also be used in hormone therapy for teenage girls once they reach sexual maturity (6). In addition, estradiol and progesterone i X An ovarian hormone that influences the menstrual cycle and pregnancy. Therefore, younger women may need higher doses of estrogen than menopausal women. Hormonal therapy: According to the American College of Obstetricians and Gynecologists, hormone therapy in female adolescents to treat primary ovarian insufficiency is focused on replacing hormones that ovaries are meant to produce before menopause (6).However, tricyclic antidepressants and benzodiazepines are not so commonly used in children (9). Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are used in children and adolescents. Medications: Healthcare practitioners may prescribe medications along with the therapy.